* Conference Event
% Exhibition/Scrimmage Event
Event times are (EST)
| August |
| | 27 | 6:00PM | Quincy | @ | Indiana State University | 26-20 | (OT) |
| | Non-conference |
| | | 7:00PM | Marian | @ | Saint Francis (IL) | 27-24 | |
| | MSFA Crossover Game |
| | 29 | 2:00PM | William Penn | vs. | Georgetown College | 14-22 | |
| | Big River Bowl - Dyersburg, Tenn. |
| | | 2:00PM | Grand View | @ | Briar Cliff University | 27-21 | |
| | Non-conference game |
| | | 7:00PM | Trinity International | @ | Iowa Wesleyan | 7-29 | |
| | MSFA crossover game |
| | | 8:00PM | McKendree | vs. | Ottawa University | 21-31 | |
| | VSN First Down Classic at Platte City, MO |
| September |
| | 3 | 7:00PM | Iowa Wesleyan | @ | Tennessee-Martin | 0-56 | |
| | Non-conference game |
| | | 7:00PM | Quincy | @ | Southeastern Missouri State University | 3-72 | |
| | Non-conference |
| | | 8:00PM | William Penn | @ | South Dakota | 0-52 | |
| | | 9:00PM | Saint Xavier | @ | Saint Francis (IL) | 52-21 | |
| | MSFA Crossover Game |
| | 5 | 2:00PM | Trinity International | @ | Saint Ambrose | 0-44 | |
| | MSFA Crossover game |
| | | 7:00PM | McKendree | @ | Olivet Nazarene | 55-3 | |
| | MSFA Crossover game |
| | | 7:00PM | Grand View | @ | Drake University | 0-22 | |
| | Non-conference game |
| | 12 | 12:00PM | Iowa Wesleyan | @ | Saint Francis (IN) | 0-55 | |
| | MSFA Crossover game--USF produced 600 yds total offense. 53 consect. home wins |
| | | 12:00PM | Saint Ambrose | @ | Malone | 34-14 | |
| | MSN Extravaganza |
| | | 2:00PM | Taylor | @ | William Penn | 16-42 | |
| | MSFA Crossover Game |
| | | 2:00PM | Walsh | @ | Quincy | 24-16 | |
| | MSFA Crossover game |
| * | | 2:00PM | Saint Francis (IL) | @ | Grand View | 21-31 | |
| | MSFA Midwest League Game |
| | | 2:00PM | Waldorf | @ | Dordt College | 17-32 |  |
| | Non-Conference game |
| | | 2:30PM | Marian | @ | McKendree | 17-21 | |
| | MSFA Crossover game |
| | 19 | 1:00PM | Grand View | @ | Marian | 16-34 | |
| | LIVE STATS |
| * | | 2:00PM | William Penn | @ | Quincy | 35-30 | |
| | MSFA Midwest League |
| | | 2:00PM | Saint Francis (IN) | @ | Saint Ambrose | 30-10 | |
| | MSFA Crossover game |
| | | 2:00PM | Taylor | @ | Saint Francis (IL) | 38-23 | |
| | MSFA Crossover Game |
| | | 2:00PM | Waldorf | @ | Trinity International | 23-14 | |
| | MSFA Crossover game |
| * | | 2:00PM | McKendree | @ | Iowa Wesleyan | 40-0 | |
| | MSFA Midwest League game |
| * | 26 | 2:00PM | Grand View | @ | Waldorf | 45-13 | |
| | MSFA Midwest League game |
| | | 7:00PM | Trinity International | @ | William Penn | 13-49 | |
| | MSFA Crossover Game |
| | | 7:00PM | Quincy | @ | Saint Xavier | 0-51 | |
| | MSFA Crossover game |
| * | | 7:00PM | Saint Francis (IL) | @ | Iowa Wesleyan | 51-6 | |
| | MSFA Midwest League Game |
| * | | 7:00PM | Saint Ambrose | @ | McKendree | 12-17 | |
| | MSFA Midwest League game |
| October |
| * | 3 | 2:00PM | William Penn | @ | Grand View | 17-24 | |
| | MSFA Midwest League |
| * | | 2:00PM | Saint Ambrose | @ | Saint Francis (IL) | 31-30 | |
| | MSFA Midwest League Game |
| * | | 3:00PM | Iowa Wesleyan | @ | Waldorf | 26-14 | |
| | MSFA Midwest League game |
| * | 10 | 2:00PM | Waldorf | @ | Saint Ambrose | 0-66 | |
| | MSFA Midwest League game |
| * | | 2:00PM | Grand View | @ | Quincy | 39-16 | |
| | MSFA Midwest League game |
| * | | 2:30PM | Iowa Wesleyan | @ | William Penn | 14-44 | |
| | MSFA Midwest League - Homecoming |
| * | | 2:30PM | Saint Francis (IL) | @ | McKendree | 20-24 | |
| | MSFA Midwest League Game |
| * | 17 | 2:00PM | William Penn | @ | Saint Ambrose | 26-21 | |
| | MSFA Midwest League |
| * | | 2:00PM | Quincy | @ | Iowa Wesleyan | 31-0 | |
| | MSFA Midwest League game |
| | | 2:00PM | Grand View | @ | Kentucky Wesleyan University | 24-12 | |
| | Non-conference game |
| * | | 2:30PM | Waldorf | @ | McKendree | 0-66 | |
| | MSFA Midwest League game -- Carl Poelker wins 100th game as McKendree head coach |
| * | 24 | 2:00PM | McKendree | @ | William Penn | 24-14 | |
| | MSFA Midwest League |
| | | 2:00PM | Iowa Wesleyan | @ | Saint Xavier | 6-66 | |
| | MSFA Crossover game |
| | | 2:00PM | Waldorf | @ | Peru State College | 6-24 | |
| | Non-Conference game |
| * | | 2:00PM | Saint Ambrose | @ | Quincy | 21-9 | |
| | MSFA Midwest League game |
| | | 7:00PM | Olivet Nazarene | @ | Saint Francis (IL) | 20-62 | |
| | MSFA Crossover Game |
| | 31 | 2:00PM | William Penn | @ | Peru State College | 12-20 | |
| | Non-Conference game |
| * | | 2:00PM | Saint Francis (IL) | @ | Waldorf | 19-0 | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Grand View | @ | Iowa Wesleyan | 27-7 | |
| | MSFA Midwest League game |
| * | | 2:30PM | Quincy | @ | McKendree | 0-38 | |
| | MSFA Midwest League game -- Senior Day at McKendree |
| November |
| * | 7 | 1:00PM | Saint Francis (IL) | @ | Quincy | 29-30 | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Waldorf | @ | William Penn | 6-65 | |
| | MSFA Midwest League |
| * | | 2:00PM | Saint Ambrose | @ | Grand View | 20-21 | |
| | MSFA Midwest League game |
| * | 14 | 2:00PM | William Penn | @ | Saint Francis (IL) | 27-6 | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Iowa Wesleyan | @ | Saint Ambrose | 0-42 | |
| | MSFA Midwest League game |
| * | | 2:00PM | Quincy | @ | Waldorf | 35-20 | |
| | MSFA Midwest League game |
| * | | 2:00PM | McKendree | @ | Grand View | 35-17 | |
| | MSFA Midwest League game |
| | 21 | 2:00PM | McKendree | @ | Saint Xavier | 28-52 | |
| | NAIA FCS First Round |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (EST)
