* Conference Event
% Exhibition/Scrimmage Event
Event times are (EST)
| August |
| | 28 | 2:00PM | Iowa Wesleyan | @ | Trinity International | 6-16 | |
| | MSFA Crossover Game |
| | | 2:00PM | Black Hills State University | @ | Grand View | 0-28 | |
| | Non-conference Games |
| | | 6:00PM | Saint Francis (IL) | @ | Marian | 17-37 | |
| | Live Video
Live Stats |
| | | 7:00PM | McKendree | vs. | University of the Cumberlands | 34-27 | |
| | 2010 Big River Bowl at Dyersburg, Tenn. |
| September |
| | 2 | | Quincy | @ | Southern Illinois University-Carbondale | 7-70 | |
| | Non-Conference Game |
| | 4 | 2:00PM | Saint Ambrose | @ | Trinity International | | |
| | MSFA Crossover Game |
| | | 2:00PM | Waldorf | @ | Trinity Bible College | | |
| | Non-conference Game |
| | | 7:00PM | Olivet Nazarene | @ | McKendree | | |
| | MSFA Crossover Game |
| | | 7:00PM | Coe College | @ | Iowa Wesleyan | | |
| | Non-conference Game |
| | | 7:00PM | William Penn | @ | Graceland University | | |
| | | 7:00PM | Saint Francis (IL) | @ | Saint Xavier | | |
| | Game is being resumed from the original Thursday night start |
| | 11 | 12:00PM | Quincy | @ | Walsh | | |
| | MSFA Crossover |
| | | 1:00PM | McKendree | @ | Marian | | |
| | MSFA Crossover Game |
| | | 1:00PM | Malone | @ | Saint Ambrose | | |
| | MSFA Crossover Game |
| | | 1:00PM | William Penn | @ | Taylor | | |
| | MSFA Crossover Game (Time is CSTl) |
| | | 2:00PM | Saint Francis (IN) | @ | Iowa Wesleyan | | |
| | MSFA Crossover |
| | | 2:00PM | Briar Cliff University | @ | Waldorf | | |
| | Non-conference Game |
| * | | 7:00PM | Grand View | @ | Saint Francis (IL) | | |
| | MSFA Midwest League Game |
| | 18 | 12:00PM | Saint Ambrose | @ | Saint Francis (IN) | | |
| | MSFA Crossover |
| | | 2:00PM | Marian | @ | Grand View | | |
| | MSFA Crossover Game |
| | | 2:00PM | Trinity International | @ | Waldorf | | |
| | MSFA Crossover Game |
| * | | 2:30PM | Quincy | @ | William Penn | | |
| * | | 7:00PM | Iowa Wesleyan | @ | McKendree | | |
| | MSFA Midwest League Game |
| | 25 | 2:00PM | Saint Xavier | @ | Quincy | | |
| | MSFA Crossover Game |
| | | 2:00PM | William Penn | @ | Trinity International | | |
| | MSFA Crossover Game |
| * | | 2:00PM | Iowa Wesleyan | @ | Saint Francis (IL) | | |
| | Open Date |
| * | | 2:00PM | Waldorf | @ | Grand View | | |
| | MSFA Midwest League Game |
| * | | 7:00PM | McKendree | @ | Saint Ambrose | | |
| | MSFA Midwest League Game |
| October |
| | 2 | | Quincy | vs. | Indiana State University | | |
| | Non-Conference |
| * | | 2:00PM | Saint Francis (IL) | @ | Saint Ambrose | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Grand View | @ | William Penn | | |
| | Homecoming |
| * | | 3:00PM | Waldorf | @ | Iowa Wesleyan | | |
| | MSFA Midwest League Game |
| * | 9 | 2:00PM | Saint Ambrose | @ | Waldorf | | |
| | MSFA Midwest League Game- Homecoming |
| * | | 2:00PM | Grand View | @ | Quincy | | |
| | MSFA Midwest League Game |
| * | | 5:00PM | McKendree | @ | Saint Francis (IL) | | |
| | MSFA Midwest League Game |
| * | | 7:00PM | William Penn | @ | Iowa Wesleyan | | |
| | MSFA Midwest League Game |
| | 16 | | Haskell Indian Nations University | @ | Saint Francis (IL) | | |
| | Non-Conference game |
| * | | 2:00PM | Iowa Wesleyan | @ | Quincy | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | McKendree | @ | Waldorf | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Saint Ambrose | @ | William Penn | | |
| | MSFA Midwest League Game |
| * | 23 | 2:00PM | Quincy | @ | Saint Ambrose | | |
| | MSFA Midwest League Game |
| | | 2:00PM | Waldorf | @ | Haskell Indian Nations University | | |
| | Non-conference Game |
| | | 2:00PM | Grand View | @ | Bacone College | | |
| | Non-conference Game |
| | | 2:30PM | Saint Francis (IL) | @ | Olivet Nazarene | | |
| | MSFA Crossover |
| * | | 2:30PM | William Penn | @ | McKendree | | |
| | MSFA Midwest League Game |
| | | 7:00PM | Saint Xavier | @ | Iowa Wesleyan | | |
| | MSFA Crossover Game |
| * | 30 | 2:00PM | Waldorf | @ | Saint Francis (IL) | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Iowa Wesleyan | @ | Grand View | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | McKendree | @ | Quincy | | |
| | MSFA Midwest League Game |
| | | 2:00PM | Peru State College | @ | William Penn | | |
| November |
| * | 6 | 2:00PM | Quincy | @ | Saint Francis (IL) | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | William Penn | @ | Waldorf | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Grand View | @ | Saint Ambrose | | |
| | MSFA Midwest League Game |
| * | 13 | 1:00PM | Waldorf | @ | Quincy | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Saint Francis (IL) | @ | William Penn | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Saint Ambrose | @ | Iowa Wesleyan | | |
| | MSFA Midwest League Game |
| * | | 2:00PM | Grand View | @ | McKendree | | |
| | MSFA Midwest League Game |
| | 20 | | Saint Francis (IL) | vs. | TBA | | |
| | NAIA Playoffs -- First Round |
| | 27 | | Saint Francis (IL) | vs. | TBA | | |
| | NAIA Playoffs -- Quarterfinal Round |
| December |
| | 4 | | Saint Francis (IL) | vs. | TBA | | |
| | NAIA Playoffs -- Semifinal Round |
| | 18 | | Saint Francis (IL) | vs. | TBA | | |
| | NAIA Playoffs -- Championship |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (EST)
