* Conference Event
% Exhibition/Scrimmage Event
Event times are (EST)
| August |
| | 27 | 7:00PM | Bethel College | @ | Saint Xavier | 13-26 | |
| | Non-conference game |
| | | 7:00PM | Marian | @ | Saint Francis (IL) | 27-24 | |
| | MSFA Crossover Game |
| | 29 | 7:00PM | Trinity International | @ | Iowa Wesleyan | 7-29 | |
| | MSFA crossover game |
| September |
| | 3 | 7:00PM | Anderson University | @ | Taylor | 16-31 | |
| | Pagel Williams new school record 187 punt return yards and two touchdowns (54,71) |
| | | 9:00PM | Saint Xavier | @ | Saint Francis (IL) | 52-21 | |
| | MSFA Crossover Game |
| | 5 | 1:00PM | The Apprentice School | @ | Malone | 19-35 | |
| | Non-Conference game |
| | | 1:00PM | Walsh | @ | West Liberty State | 17-48 | |
| | Non-conference game |
| | | 2:00PM | Trinity International | @ | Saint Ambrose | 0-44 | |
| | MSFA Crossover game |
| | | 7:00PM | McKendree | @ | Olivet Nazarene | 55-3 | |
| | MSFA Crossover game |
| | 12 | 12:00PM | Iowa Wesleyan | @ | Saint Francis (IN) | 0-55 | |
| | MSFA Crossover game--USF produced 600 yds total offense. 53 consect. home wins |
| | | 12:00PM | Saint Ambrose | @ | Malone | 34-14 | |
| | MSN Extravaganza |
| | | 1:30PM | West Virginia Institute of Technology | @ | Olivet Nazarene | 61-38 | |
| | Non-conference game |
| | | 2:00PM | Taylor | @ | William Penn | 16-42 | |
| | MSFA Crossover Game |
| * | | 2:00PM | Saint Xavier | @ | Trinity International | 51-3 | |
| | MSFA Mideast League game |
| | | 2:00PM | Walsh | @ | Quincy | 24-16 | |
| | MSFA Crossover game |
| | | 2:30PM | Marian | @ | McKendree | 17-21 | |
| | MSFA Crossover game |
| | 19 | 12:00PM | Ohio Dominican University | @ | Walsh | 16-23 | |
| | Non-Conference |
| | | 1:00PM | Grand View | @ | Marian | 16-34 | |
| | LIVE STATS |
| | | 2:00PM | Saint Francis (IN) | @ | Saint Ambrose | 30-10 | |
| | MSFA Crossover game |
| | | 2:00PM | Taylor | @ | Saint Francis (IL) | 38-23 | |
| | MSFA Crossover Game |
| | | 2:00PM | Waldorf | @ | Trinity International | 23-14 | |
| | MSFA Crossover game |
| * | | 7:00PM | Olivet Nazarene | @ | Saint Xavier | 20-58 | |
| | Mideast League game - St. Xavier University ranked #14 in NAIA |
| * | 26 | 12:00PM | Marian | @ | Saint Francis (IN) | 7-28 | |
| | MSFA Mideast League game |
| | | 12:00PM | Walsh | @ | Urbana University | 59-21 | |
| | Non-conference game |
| | | 1:00PM | Malone | @ | Anna Maria College | 65-10 | |
| | Non-conference game |
| | | 2:30PM | Southern Nazarene University | @ | Olivet Nazarene | 35-56 | |
| | Non-Conference game |
| | | 7:00PM | Trinity International | @ | William Penn | 13-49 | |
| | MSFA Crossover Game |
| | | 7:00PM | Quincy | @ | Saint Xavier | 0-51 | |
| | MSFA Crossover game |
| October |
| * | 3 | 12:00PM | Olivet Nazarene | @ | Walsh | 12-63 | |
| | Mideast League game |
| * | | 1:00PM | Saint Xavier | @ | Taylor | 51-35 | |
| | Saint Xaiver No. 9 | Live Stats |
| * | | 2:00PM | Marian | @ | Trinity International | 31-7 | |
| | MSFA Mideast League game |
| * | | 7:00PM | Saint Francis (IN) | @ | Malone | 42-14 | |
| | MSFA Mideast League game-Daniel Carter moves into MSFA Top 10 career rushing |
| * | 10 | 12:00PM | Saint Xavier | @ | Marian | 42-7 | |
| | LIVE STATS |
| * | | 1:00PM | Taylor | @ | Malone | 23-17 | |
| | MSFA Mideast League game |
| * | | 2:00PM | Olivet Nazarene | @ | Trinity International | 28-7 | |
| | Mideast League game |
| * | | 6:00PM | Saint Francis (IN) | @ | Walsh | 20-14 | |
| | MSFA Mideast League game-4th Q defensive stand preserves win for #4 Cougars |
| * | 17 | 12:00PM | Trinity International | @ | Saint Francis (IN) | 7-63 | |
| | MSFA Mideast League game- 55th consecutive home win for USF |
| * | | 1:00PM | Walsh | @ | Taylor | 31-12 | |
| | MSFA Mideast League game |
| * | | 2:00PM | Malone | @ | Saint Xavier | 31-66 | |
| | MSFA Mideast League game |
| * | | 2:30PM | Marian | @ | Olivet Nazarene | 34-0 | |
| | MSFA Mideast League game |
| * | 24 | 1:00PM | Walsh | @ | Malone | 31-14 | |
| | MSFA Mideast League game |
| * | | 1:00PM | Trinity International | @ | Taylor | 7-48 | |
| | MSFA Mideast League game |
| | | 1:00PM | Marian | @ | Albion College | 28-10 | |
| | Live Stats |
| | | 2:00PM | Iowa Wesleyan | @ | Saint Xavier | 6-66 | |
| | MSFA Crossover game |
| | | 2:00PM | Saint Francis (IN) | @ | Missouri U. of Science & Technology | 37-39 | |
| | Non-conference game |
| | | 7:00PM | Olivet Nazarene | @ | Saint Francis (IL) | 20-62 | |
| | MSFA Crossover Game |
| * | 29 | 6:00PM | Saint Xavier | @ | Walsh | 34-17 | |
| | MSFA Mideast League game |
| * | 31 | 12:00PM | Olivet Nazarene | @ | Saint Francis (IN) | 7-56 | |
| | Mideast League game-Carter 6th consec 100-yd rush gm, 7,000+all-purpose career yds |
| * | | 1:00PM | Taylor | @ | Marian | 36-35 | |
| | Taylor wins with 44-yard TD pass as clock expired. Ryan Magnuson catches all 6 Taylor TDs. |
| * | | 7:30PM | Trinity International | @ | Malone | 12-48 | |
| | MSFA Mideast League game |
| November |
| * | 7 | 12:00PM | Saint Xavier | @ | Saint Francis (IN) | 36-24 | |
| | MSFA Mideast League game-SXU 1st league title...snaps USF 56-game home win streak |
| * | | 1:00PM | Malone | @ | Marian | 24-28 | |
| | Live Stats |
| * | | 2:00PM | Walsh | @ | Trinity International | 38-7 | |
| | MSFA Mideast League game |
| * | | 2:30PM | Taylor | @ | Olivet Nazarene | 45-35 | |
| | Mideast League game |
| * | 14 | 12:00PM | Marian | @ | Walsh | 7-41 | |
| | MSFA Mideast League game |
| * | | 1:00PM | Saint Francis (IN) | @ | Taylor | 16-23 | |
| | Taylor's first win against USF since 1998 |
| * | | 2:30PM | Malone | @ | Olivet Nazarene | 57-35 | |
| | MSFA Mideast League game |
| | 21 | 2:00PM | McKendree | @ | Saint Xavier | 28-52 | |
| | NAIA FCS First Round |
| | 28 | 1:00PM | Lambuth University | @ | Saint Xavier | 10-52 | |
| | NAIA Football Championship Series Quarterfinals |
| December |
| | 5 | 1:00PM | Saint Xavier | @ | University of Sioux Falls | 6-48 | |
| | NAIA Championship Series - Semifinal |
* Conference Event
% Exhibition/Scrimmage Event
Event times are (EST)
