Two teams, Grand View University of Des Moines, IA and Waldorf College of Forest City, IA, joined the association for the 2009-2010 leaving the Midwest League with eight teams including Iowa Wesleyan College of Mount Pleasant, Iowa; St. Ambrose University of Davenport; and William Penn University of Oskaloosa, Iowa along with McKendree University of Lebanon, IL; Quincy University, IL and the University of St. Francis of Joliet, IL

With the addition of Grand View and Waldorf, three Illinois schools - Olivet Nazarene University of Bourbonnais, Saint Xavier University of Chicago and Trinity International University of Deerfield - moved to the Mideast League to balance out the MSFA. The eight-team Mideast League also includes Marian University of Indianapolis, IN; the University of Saint Francis of Fort Wayne, IN; and Taylor University of Upland, IN; along with Malone University and Walsh University of Canton, Ohio.

            Two Michigan institutions, Concordia University of Ann Arbor and Siena Heights University of Adrian, have been extended membership. Both will become members of the Mideast League, Concordia in the 2011 season and Siena Heights in 2012.

            Malone, Olivet Nazarene, Saint Xavier, Taylor and Trinity International were among 11 MSFA charter members when the association was formed in April 1993 and began its first season of competition in 1994. Saint Xavier was added in 1995, Iowa Wesleyan, St. Ambrose and Walsh in 1996, Saint Francis (IN) and McKendree in 1998, St. Francis (IL) in 2000, William Penn in 2002,  Quincy in 2003 and Marian in 2007.

 Each MSFA team plays the other teams within its league plus crossover games against the other league. The champions of the two leagues receive automatic berths into the NAIA Championship playoffs.